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磷酸三钙（英文：Tricalcium phosphate ，简称TCP）又称磷酸钙。化学式Ca3(PO4)2。白色晶体或无定形粉末。存在多种晶型转变，主要分为低温β相（β-TCP）和高温α相（α-TCP），相转变温度为1120℃-1170℃，熔点1670℃；溶于酸，不溶于水和乙醇。在人的骨骼中普遍存在，是一种良好的骨修复材料。
简介
编辑化学名：磷酸三钙酸三钙——来自维基百科别名：磷酸钙分子式：Ca3(PO4)2分子量：310.18CAS：7758-87-4物理性质外观与性状：白色、无臭、无味的晶体或无定形粉末。熔点(℃)：1670溶解性：不溶于水，不溶于乙醇、乙酸，溶于酸。高温型的α相属单斜晶系，相对密度为2.86 g/cm3；低温型的β相属六方晶系，相对密度为3.07 g/cm3。
化学性质
编辑磷酸钙与磷酸氢钙鉴别实验原理：磷酸钙难溶于水，磷酸氢钙微溶于水，其水溶液呈微碱性实验用品及试剂：烧杯、玻璃瓶、试管、石蕊试剂、酚酞、PH试纸实验步骤：1．分别取磷酸钙和磷酸氢钙少量，加入烧杯中，加少量水，充分溶解。2．在两个烧杯中分别滴加酚酞实验现象：一个烧杯中液体变红，是磷酸氢钙，另一烧杯不变色，是磷酸钙。结论：磷酸钙难溶于水，磷酸氢钙微溶于水，其水溶液呈微碱性。
应用
食品
磷酸三钙是一种安全的营养强化剂，主要添加在食品中强化钙的摄入，也可用于预防或治疗钙缺乏的症状。同时磷酸三钙还可作为食品中的抗结剂、 PH 值调节剂，缓冲剂等。如作面粉抗结剂（分散剂），奶粉、糖果，布丁、调味品、肉类的添加剂，动物油精炼助剂，酵母食料等。微囊包埋磷酸三钙，人体最佳钙源之一由西班牙Lipofoods公司生产的微囊包埋钙（LIPOCAL），是一种以磷酸三钙为原料，经过超细粉碎后，再用卵磷脂包裹成直径为3－5微米的微胶囊的一种钙制品。LIPOCAL的高吸收性，归功于其使用了卵磷脂进行包埋。由于卵磷脂的分子结构与肠上皮细胞的细胞膜中磷脂分子结构相似，当卵磷脂与细胞膜交换或者直接嵌入时，可以增加肠上皮细胞膜的流动性，因此可以增强营养物质的吸收性。当钙从微胶囊中释放出来，便能够很容易地穿透肠粘膜或细胞间隙进入血液循环。西班牙巴塞罗那大学一项实验显示：磷酸三钙经过微囊化包埋后，生物利用度可提高41%。此外，磷酸三钙作为日常钙源之一，相比其它补钙产品，其优势在于可同时提供钙和磷。身体内的钙和磷保持平衡非常重要，因为这两种矿物质都是骨骼形成的必需物质，所以如果不能达到两种物质的均衡，而只是单纯补钙则通常难以达到理想的补钙效果。
医学
磷酸三钙具有良好的生物相容性、生物活性以及生物降解性,是理想的人体硬组织修复和替代材料,在生物医学工程学领域一直受到人们的密切关注。医学上通常使用的是磷酸三钙的一种特殊形态—β-磷酸三钙。β-磷酸三钙主要是由钙、磷组成，其成分与骨基质的无机成分相似，与骨结合好。动物或人体细胞可以在β-磷酸三钙材料上正常生长，分化和繁殖。通过大量实验研究证明：β-磷酸三钙对骨髓造血机能无不良反应，无排异反应，无急性毒性反应，不致癌变，无过敏现象。因此β-磷酸三钙可广泛应用于关节与脊柱融合、四肢创伤、口腔颌面的外科、心血管外科，以及填补牙周的空洞等方面。随着人们对β-磷酸三钙研究的不断深入，其应用形式也出现了多样化，并在临床医学中体现了较好的性能。梁戈等通过实验发现其溶血程度<5%，当β-磷酸三钙被植入人体内后，其在体液中能发生降解和吸收，钙、磷被体液吸收后进入人体循环系统，一定时间后植入人体的β-磷酸三钙逐渐溶解消失，形成新骨。Arai等利用β-磷酸三钙多孔陶瓷填充8～15cm 的腓骨节段缺损，获得了腓骨再生。平均术后2个月即可达到重建。不会发生踝关节及胫骨的移位。郑承泽等将β-磷酸三钙与自体骨髓复合应用于临床，修复包括肿瘤性骨缺损和陈旧性骨折骨缺损,经术后调查，结果显示植入材料的成骨作用明显，说明β-磷酸三钙与自体骨髓复合是一种治疗骨缺损理想的方法。张汉东等将磷酸三钙陶瓷用于修复兔下颌骨缺损,研究表明，植入后局部组织无明显炎症等反应。张建设等将两种不同组成的β-磷酸三钙陶瓷植入免颌骨人工缺损区，掺杂的磷酸三钙陶瓷降解速度较慢，但具有较好的生物相容性。张亮等利用β-磷酸三钙/DL—PLA 作为一种新型治疗骨缺损的材料，研究表明其降解特点有利于骨组织细胞长入。Mitenmuller 等利用带微孔的陶瓷颗粒作为抗结核药及抗菌素的载体，填塞至骨髓炎患部，缺损骨基本修复。
其他
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NITIKA PHARMACEUTICAL SPECIALITIES PVT. LTD. ( NITIKA CHEMICALS ) was found in 1991 as a small manufacturing unit has grown today into a dynamic production center for range of products finding applications in various Industry Verticals.
While achieving this growth we are still maintaining it as a family owned enterprise to make best of the advantages of being a closely held company.
15 years after its foundation the company has been able to adapt to the fast growing technological changes to have an edge in the global market place.
Our focus is on the customer and achieving the high degree of customer satisfaction by providing quality products at a reasonable cost backed by timely deliveries and after sales support.
In 1991 NITIKA PHARMACEUTICAL SPECIALITIES PVT. LTD. ( NITIKA CHEMICALS ) was started to Manufacture Fine Chemicals for the Pharmaceutical and Allied Industries.
In 1993 received the Indian FDA Approval.
In 1996 the Production of Metallic Stearates was started utilizing the totally Home-Grown technologies.
In 2000 first Export for USA
n 2003 received ISO 9001:2000 from Bureau Veritas Quality International (Holding) S.A. London.
In 2005 we started building the plant as per WHO-GMP and US-FDA requirements and also received US-DMF no.18912 for our product Magnesium Stearate.
In 2006 we received KOSHER Certificate
In 2007 EDMF No.1252 from European authorities.
In 2008 received ISO 14001:2004.
In 2009 received WHO – GMP Approval.
NITIKA PHARMACEUTICAL SPECIALITIES PVT. LTD. ( NITIKA CHEMICALS ) wishes to maintain a profitable competitive and continuing organization where challenging and rewarding environment encourages employees to work with pride, enthusiasm and commitment.
We acknowledge that the present and future well-being of the company and its employees depends on our pharmaceutical and chemical products meeting statutory, regulatory and customer requirements. We support this by implementing Good Manufacturing and good laboratory practices.
Why Nitika?
Only company in Asia and second in world have Active US-DMF No.18912 for Magnesium Stearate
All the major global players producing Magnesium Stearate are chemical companies having a small Pharma division where as NITIKA PHARMACEUTICAL SPECIALITIES PVT. LTD. ( NITIKA CHEMICALS ) is a purely Pharma focused company and a step further we are focusing on only Pharmaceutical specialized Excipients.
Being strategically located in Central India, provides us with immense benefits like availability of pool of technically qualified personnel, low cost manpower, ready availability of various raw material and utilities.
We stand to gain from the fact that, India is being projected as the future pharmaceutical hub in the global knowledge economy.
India’s first International Multi-model Cargo Hub ‘MIHAN’ is coming up at a distance of about 15 miles from our plant.
Vision
We see Nitika Chemicals as a research based integrated chemical and pharmaceutical company of tomorrow having presence all over the globe with its focus on pharmaceutical excipients and specialties by providing its customers high quality products and backing them with technical, documentation and other supports.
